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Scaffolds for cell transplantation in neurology—The suitability of a thermoreversible gelation polymer: Our perspectives
Vidyasagar Devaprasad Dedeepiya1, Justin Benjamin William2, Jutty KB C Parthiban3, Hiroshi Yoshioka4, Yuichi Mori5, Satoshi Kuroda6, Masaru Iwasaki7, Senthilkumar Preethy8, Samuel J K Abraham9
1 Consultant, Department of Biotechnology, Acharya Nagarjuna University, Guntur; The Mary-Yoshio Translational Hexagon, Nichi-In Centre for Regenerative Medicine, Chennai, Tamil Nadu, India
2 Professor, Department of Surgery and Radiology, Madras Veterinary College, Chennai, Tamil Nadu, India
3 Consultant, Department of Neurosurgery, The Mary-Yoshio Translational Hexagon, Nichi-In Centre for Regenerative Medicine, Chennai, Tamil Nadu, India
4 Associate Visiting Professor, Waseda University, Tokyo, Japan
5 Visiting Professor, Waseda University, Tokyo, Japan
6 Professor, Department of Neurosurgery, Graduate School of Medicine Toyama University, Toyama, Japan
7 Professor, Department of Clinical Research, Faculty of Medicine, Yamanashi University, Chuo, Japan
8 Research Co-ordinator, The Fujio-Eiji Academic Terrain, Nichi-In Centre for Regenerative Medicine, Hope Foundation (Trust), Chennai, Tamil Nadu, India
9 Director, The Mary-Yoshio Translational Hexagon, Nichi-In Centre for Regenerative Medicine; Faculty of Medicine, Yamanashi University, Chuo, Japan
Correspondence Address:
Samuel J K Abraham
Director, The Mary-Yoshio Translational Hexagon, Nichi-In Centre for Regenerative Medicine, Faculty of Medicine, Yamanashi University, PB 1262, Chennai-600034, Tamil Nadu
Japan
 Source of Support: None, Conflict of Interest: None  | 1 |
DOI: 10.5005/jp-journals-10039-1003
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Clinical translation of cell-based therapies in neurology, especially the spinal cord injury and damage to the brain, have been marred by several hurdles [Dedeepiya VD et al Expert Opinion on Biological Therapy (In print)] and one significant among them is the need for a suitable biocompatible scaffold, which can retain the transplanted cells, give an active or passive support to the cells, enable their proliferation, differentiation when needed and integration into the local niche until the restoration of the damage are complete, without any adverse reactions to the vicinity or to any of the systems of the animal or human being where it is applied. Scaffolds for neurological applications need to be biocompatible, biodegradable, non-immunogenic, must provide contact guidance for neurite outgrowth, should have porosity for vascularization and cell migration. Several natural scaffolds like collagen, alginate, silk fibroin, hyaluronic acid, chitosan, etc. and synthetic scaffolds like poly (lactic acid) (PLA), poly (glycolic acid) (PGA), poly (lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), poly (lactide-co-caprolactone) (PLCL) have been employed for cell transplantation in neurology primarily for nerve injuries and stroke. In this review, we briefly outline the different studies utilizing these scaffolds employed for cell transplantation in neurology and we document the suitability of a unique poly (N-isopropylacrylamide-co-n-butyl methacrylate) (poly NIPAAm-co-BMA) and polyethylene glycol (PEG)-based thermoreversible gelation polymer for cell therapy applications in neurology.
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